HRID2411447

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16664117

未命名化合物

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(Br)cc2S(C)(=O)=O)CC1

HCID58484821

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(N3[C@H](CO)CCS3(=O)=O)cc2S(C)(=O)=O)CC1

HCID71252606

未命名化合物

收率 31%

PROCEDURE

实验过程

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (241 mg) described in Preparation Example 1 and (4-bromo-2-methanesulfonylphenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (478 mg) described in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 32, the title compound (170 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 126 and by the reaction and treatment in the same manner as in Example 32

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-81ac9038ee2445ee83e3cd4899d3adcb
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[C:37]([CH3:38])=[CH:36][C:35]([CH:39]4[CH2:41][CH2:40]4)=[CH:34][N:33]=3)[CH2:28][CH2:27]2)=[O:25])=[C:20]([S:42]([CH3:45])(=[O:44])=[O:43])[CH:19]=1>>[CH:39]1([C:35]2[CH:36]=[C:37]([CH3:38])[C:32]([N:29]3[CH2:30][CH2:31][N:26]([C:24]([C:21]4[CH:22]=[CH:23][C:18]([N:11]5[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]5(=[O:15])=[O:16])=[CH:19][C:20]=4[S:42]([CH3:45])(=[O:44])=[O:43])=[O:25])[CH2:27][CH2:28]3)=[N:33][CH:34]=2)[CH2:40][CH2:41]1