HCID 16664117, compound → HCID 71252183, compound

HRID 2411448Notes

Reaction equation

HRID 2411448 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[CH:20][C:19]=1[F:40]>>[CH3:39][C:33]1[CH:34]=[C:35]([CH3:38])[CH:36]=[CH:37][C:32]=1[N:29]1[CH2:28][CH2:27][N:26]([C:24]([C:21]2[CH:22]=[CH:23][C:18]([N:11]3[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]3(=[O:15])=[O:16])=[C:19]([F:40])[CH:20]=2)=[O:25])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484634HCID 58484634, compound

Product 1

HCID 71252183HCID 71252183, compoundYield 13.4%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (1.07 g) described in Preparation Example 1 and (4-bromo-3-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.74 g) described in Preparation Example 132 and by the reaction and treatment in the same manner as in Example 32, the title compound (274 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 132 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-7898c152a6884e97a8e87882c31f432f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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