HCID 44222369, compound → HCID 71252800, compound

HRID 2411452Notes

Reaction equation

HRID 2411452 reaction equation
C([O:8][CH2:9][C@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][N:28]([C:31]([C:33]2[CH:38]=[CH:37][C:36](I)=[CH:35][CH:34]=2)=[O:32])[CH2:27][CH2:26]1>>[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:26][CH2:27][N:28]([C:31]([C:33]2[CH:38]=[CH:37][C:36]([N:11]3[C@@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]3(=[O:15])=[O:16])=[CH:35][CH:34]=2)=[O:32])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 44222369HCID 44222369, compoundHCID 58484733[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252800HCID 71252800, compoundYield 76.9%

Procedure

Using (R)-3-benzyloxymethylisothiazolidine 1,1-dioxide (370 mg) described in Preparation Example 10 and [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (643 mg) described in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 32, the title compound (522 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 108 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-5f0b122a71434b7891f29d60981477e3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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