1,3-Propanesultam → HCID 71252038, compound

HRID 2411455Notes

Reaction equation

HRID 2411455 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:21][CH2:22][N:17]([C:15]([C:12]3[CH:11]=[CH:10][C:9]([N:2]4[CH2:3][CH2:4][CH2:5][S:1]4(=[O:7])=[O:6])=[CH:14][N:13]=3)=[O:16])[CH2:18][CH2:19]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 58484566HCID 58484566, compound

Product 1

HCID 71252038HCID 71252038, compoundYield 37.1%

Procedure

Using isothiazolidine 1,1-dioxide (121 mg) and (5-bromopyridin-2-yl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (375 mg) described in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1, the title compound (154 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-a1e10fa4faae4369af4b41003e33c00a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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