1,3-Propanesultam → HCID 71251999, compound

HRID 2411456Notes

Reaction equation

HRID 2411456 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH:30]4[CH2:32][CH2:31]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH:30]1([C:26]2[CH:27]=[C:28]([CH3:29])[C:23]([N:20]3[CH2:19][CH2:18][N:17]([C:15]([C:12]4[CH:11]=[CH:10][C:9]([N:2]5[CH2:3][CH2:4][CH2:5][S:1]5(=[O:7])=[O:6])=[CH:14][N:13]=4)=[O:16])[CH2:22][CH2:21]3)=[N:24][CH:25]=2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 58484818HCID 58484818, compound

Product 1

HCID 71251999HCID 71251999, compoundYield 40.8%

Procedure

Using isothiazolidine 1,1-dioxide (94 mg) and (5-bromopyridin-2-yl) [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (310 mg) described in Preparation Example 135 and by the reaction and treatment in the same manner as in Example 1, the title compound (139 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 135 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-b5d7508c9a2f4350a2d8b4f044a7568c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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