1,3-Propanesultam → HCID 71252578, compound

HRID 2411457Notes

Reaction equation

HRID 2411457 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[N:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][CH:20]([O:23][C:24]3[CH:29]=[CH:28][C:27]([CH:30]4[CH2:32][CH2:31]4)=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1>>[CH:30]1([C:27]2[CH:28]=[CH:29][C:24]([O:23][CH:20]3[CH2:21][CH2:22][N:17]([C:15]([C:12]4[CH:13]=[N:14][C:9]([N:2]5[CH2:3][CH2:4][CH2:5][S:1]5(=[O:7])=[O:6])=[CH:10][CH:11]=4)=[O:16])[CH2:18][CH2:19]3)=[CH:25][CH:26]=2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 58484616HCID 58484616, compound

Product 1

HCID 71252578HCID 71252578, compoundYield 60.5%

Procedure

Using isothiazolidine 1,1-dioxide (230 mg) and (6-bromopyridin-3-yl)[4-(4-cyclopropylphenoxy)piperidin-1-yl]methanone (635 mg) described in Preparation Example 192 and by the reaction and treatment in the same manner as in Example 1, the title compound (423 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 192 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-2ef84de91fae468f93ad09b01f54f78d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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