1,3-Propanesultam → HCID 71251992, compound

HRID 2411459Notes

Reaction equation

HRID 2411459 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[CH3:30])[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH3:30][C:24]1[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=1[N:20]1[CH2:19][CH2:18][N:17]([C:15]([C:12]2[CH:11]=[CH:10][C:9]([N:2]3[CH2:3][CH2:4][CH2:5][S:1]3(=[O:7])=[O:6])=[CH:14][N:13]=2)=[O:16])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 58484574HCID 58484574, compound

Product 1

HCID 71251992HCID 71251992, compoundYield 37.8%

Procedure

Using isothiazolidine 1,1-dioxide (52 mg) and (5-bromopyridin-2-yl) [4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (160 mg) described in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1, the title compound (67 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-3b63a5811ffa49ccb6008489e6115dcd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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