1,3-Propanesultam → HCID 71252614, compound

HRID 2411460Notes

Reaction equation

HRID 2411460 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH2:30][CH3:31])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[O:6]=[S:1]1(=[O:7])[CH2:5][CH2:4][CH2:3][N:2]1[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH2:30][CH3:31])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71252936HCID 71252936, compound

Product 1

HCID 71252614HCID 71252614, compoundYield 69.3%

Procedure

Using isothiazolidine 1,1-dioxide (53 mg) and (5-bromopyridin-2-yl) [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (170 mg) described in Preparation Example 138 and by the reaction and treatment in the same manner as in Example 1, the title compound (130 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 138 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-7369258567cc4e4b94077029437d9ea3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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