HCID 16664117, compound → HCID 71252037, compound

HRID 2411461Notes

Reaction equation

HRID 2411461 reaction equation
C([O:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[NH:11]1)C1C=CC=CC=1.Br[C:18]1[CH:19]=[CH:20][C:21]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:33]=3[CH3:39])[CH2:28][CH2:27]2)=[O:25])=[N:22][CH:23]=1>>[CH3:39][C:33]1[CH:34]=[C:35]([CH3:38])[CH:36]=[CH:37][C:32]=1[N:29]1[CH2:28][CH2:27][N:26]([C:24]([C:21]2[CH:20]=[CH:19][C:18]([N:11]3[C@H:10]([CH2:9][OH:8])[CH2:14][CH2:13][S:12]3(=[O:15])=[O:16])=[CH:23][N:22]=2)=[O:25])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 16664117HCID 16664117, compoundHCID 58484574HCID 58484574, compound

Product 1

HCID 71252037HCID 71252037, compoundYield 41.8%

Procedure

Using (S)-3-benzyloxymethylisothiazolidine 1,1-dioxide (439 mg) described in Preparation Example 1 and (5-bromopyridin-2-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (680 mg) described in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 32, the title compound (338 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 137 and by the reaction and treatment in the same manner as in Example 32

Sources & evidence

ORD record
ord-72525914860746828d17c9726db9ec0a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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