3-Chloropropanesulphonyl chloride → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-4-methylpyridin-3-yl]methanone

Participants

Reaction Steps

Using (6-amino-4-methylpyridin-3-yl) [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (1.0 g) described in Preparation Example 141 and 3-chloropropane-1-sulfonyl chloride (0.69 mL) and by the reaction and treatment in the same manner as in Example 78, the title compound (636 mg) was obtained.

Provenance & Evidence