1,3-Propanesultam → HCID 71252919, compound

HRID 2411463Notes

Reaction equation

HRID 2411463 reaction equation
[S:1]1(=[O:7])(=[O:6])[CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:9]1[CH:10]=[CH:11][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH:29]4[CH2:31][CH2:30]4)=[CH:27][C:26]([CH:32]4[CH2:34][CH2:33]4)=[CH:25][N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[N:13][CH:14]=1>>[CH:29]1([C:28]2[C:23]([N:20]3[CH2:21][CH2:22][N:17]([C:15]([C:12]4[CH:11]=[CH:10][C:9]([N:2]5[CH2:3][CH2:4][CH2:5][S:1]5(=[O:7])=[O:6])=[CH:14][N:13]=4)=[O:16])[CH2:18][CH2:19]3)=[N:24][CH:25]=[C:26]([CH:32]3[CH2:34][CH2:33]3)[CH:27]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71252484HCID 71252484, compound

Product 1

HCID 71252919HCID 71252919, compoundYield 39.2%

Procedure

Using isothiazolidine 1,1-dioxide (105 mg) and (5-bromopyridin-2-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (338 mg) described in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1, the title compound (145 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 142 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-23e1e04015ea46819b6f823fc65c4f56
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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