1,4-Butanesultam → HCID 71252475, compound

HRID 2411465Notes

Reaction equation

HRID 2411465 reaction equation
[S:1]1(=[O:8])(=[O:7])[CH2:6][CH2:5][CH2:4][CH2:3][NH:2]1.Br[C:10]1[CH:11]=[CH:12][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[N:14][CH:15]=1>>[CH3:30][C:29]1[C:24]([N:21]2[CH2:22][CH2:23][N:18]([C:16]([C:13]3[CH:12]=[CH:11][C:10]([N:2]4[CH2:3][CH2:4][CH2:5][CH2:6][S:1]4(=[O:8])=[O:7])=[CH:15][N:14]=3)=[O:17])[CH2:19][CH2:20]2)=[N:25][CH:26]=[C:27]([CH3:31])[CH:28]=1

Participants

3

Reactant 2

HCID 3035081,4-ButanesultamHCID 58484566HCID 58484566, compound

Product 1

HCID 71252475HCID 71252475, compoundYield 71.9%

Procedure

Using [1,2]thiazinane 1,1-dioxide (94 mg) and (5-bromopyridin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (260 mg) described in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1, the title compound (214 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 134 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-c36f50d357a541e8a119b46b9cfb7dd1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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