HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methylbenzoyl)piperidine hydrochloride → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-ylmethyl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methylbenzoyl)piperidine hydrochloride | HCID 2740817 | — |
| Reactant | 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-ylmethyl)benzoic acid | HCID 24688889 | — |
| Product | [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-ylmethyl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone | HCID 71252743 | 50.8% |
Reaction Steps
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)benzoic acid (268 mg) described in Preparation Example 18 and (piperidin-4-yl)(p-tolyl)methanone hydrochloride (252 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (235 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e414cc5eb83840828ad2442df063301e |
| Source note | uspto-grants-2014_08 |