4-(4-Methylbenzoyl)piperidine hydrochloride → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

HRID 2411470Notes

Reaction equation

HRID 2411470 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([O:16][CH3:17])[CH:8]=1.Cl.[NH:20]1[CH2:25][CH2:24][CH:23]([C:26]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)=[O:27])[CH2:22][CH2:21]1>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:20]2[CH2:25][CH2:24][CH:23]([C:26](=[O:27])[C:28]3[CH:29]=[CH:30][C:31]([CH3:34])=[CH:32][CH:33]=3)[CH2:22][CH2:21]2)=[O:13])=[C:9]([O:16][CH3:17])[CH:8]=1

Participants

3

Reactant 2

HCID 27408174-(4-Methylbenzoyl)piperidine hydrochlorideHCID 712520824-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

Product 1

HCID 71252281[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanoneYield 10.8%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxybenzoic acid (285 mg) described in Preparation Example 19 and (piperidin-4-yl)(p-tolyl)methanone hydrochloride (252 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (52 mg) was obtained.

Sources & evidence

ORD record
ord-58a5407f65774cf6930c96825054a7af
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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