4-(4-Methylbenzoyl)piperidine hydrochloride → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methylphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone

HRID 2411472Notes

Reaction equation

HRID 2411472 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=1[CH3:16].Cl.[NH:19]1[CH2:24][CH2:23][CH:22]([C:25]([C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=2)=[O:26])[CH2:21][CH2:20]1>>[O:17]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:26])[C:27]3[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=3)[CH2:21][CH2:20]2)=[O:13])=[CH:9][C:8]=1[CH3:16]

Participants

3

Reactant 2

HCID 27408174-(4-Methylbenzoyl)piperidine hydrochlorideHCID 246888114-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

Product 1

HCID 71252250[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-3-methylphenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanoneYield 10.8%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-3-methylbenzoic acid (268 mg) described in Preparation Example and (piperidin-4-yl)(p-tolyl)methanone hydrochloride (252 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (50 mg) was obtained.

Sources & evidence

ORD record
ord-2350026ceed444639182941ee54d0b33
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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