3-Chloropropanesulphonyl chloride → HCID 71252519, compound

HRID 2411475Notes

Reaction equation

HRID 2411475 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([CH3:24])[CH:3]=1.Cl[CH2:26][CH2:27][CH2:28][S:29](Cl)(=[O:31])=[O:30]>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:12][CH2:11][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:1]3[CH2:26][CH2:27][CH2:28][S:29]3(=[O:31])=[O:30])=[CH:3][C:4]=2[CH3:24])=[O:9])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 86676757HCID 86676757, compound

Product 1

HCID 71252519HCID 71252519, compound

Procedure

Using (4-amino-2-methylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (833 mg) described in Preparation Example 148 and 3-chloropropane-1-sulfonyl chloride (0.42 mL) and by the reaction and treatment in the same manner as in Example 78, the title compound (624 mg) was obtained.

Sources & evidence

ORD record
ord-56ad2324acde49a2b0b00e14ca2fd149
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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