Ethyl Acetate → [4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone hydrobromide

Participants

Reaction Steps

[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methanesulfonylphenyl]methanone (500 mg) described in Example 11 was dissolved in acetone (75 mL), hydrogen bromide/acetic acid solution (about 30%-containing, 0.3 mL) was added, and the mixture was stirred at room temperature. To the reaction mixture was added ethyl acetate, and the precipitate was collected by filtration to give the title compound (283 mg).

Provenance & Evidence