3-Chloropropanesulphonyl chloride → [4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-trifluoromethylphenyl]methanone

Participants

Reaction Steps

Using (4-amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (850 mg) described in Preparation Example 149 and 3-chloropropane-1-sulfonyl chloride (0.37 mL) and by the reaction and treatment in the same manner as in Example 78, the title compound (544 mg) was obtained.

Provenance & Evidence