1-(2,4-Xylyl)piperazine → HCID 71252579, compound

HRID 2411480Notes

Reaction equation

HRID 2411480 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([N+:16]([O-:18])=[O:17])[CH:8]=1.[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:29][CH2:30][N:31]([C:11]([C:10]2[CH:14]=[CH:15][C:7]([N:3]3[CH2:4][CH2:5][CH2:6][S:2]3(=[O:1])=[O:19])=[CH:8][C:9]=2[N+:16]([O-:18])=[O:17])=[O:13])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 71252372HCID 71252372, compound

Product 1

HCID 71252579HCID 71252579, compoundYield 16.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-nitrobenzoic acid (967 mg) described in Preparation Example 24 and 1-(2,4-dimethylphenyl)piperazine (639 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (250 mg) was obtained.

Sources & evidence

ORD record
ord-750c8d65896f4ccca41d5ac03d77af9b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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