3-Chloropropanesulphonyl chloride → HCID 71251909, compound

HRID 2411481Notes

Reaction equation

HRID 2411481 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=2[CH3:24])[CH2:13][CH2:12]1)=[O:10].Cl[CH2:26][CH2:27][CH2:28][S:29](Cl)(=[O:31])=[O:30]>>[O:30]=[S:29]1(=[O:31])[CH2:28][CH2:27][CH2:26][N:1]1[C:2]1[CH:7]=[C:6]([N:8]2[CH2:26][CH2:27][CH2:28][S:29]2(=[O:31])=[O:30])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=2[CH3:24])[CH2:13][CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 86676759HCID 86676759, compound

Product 1

HCID 71251909HCID 71251909, compound

Procedure

Using (2,4-diaminophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (847 mg) described in Preparation Example 150 and 3-chloropropane-1-sulfonyl chloride (0.85 mL) and by the reaction and treatment in the same manner as in Example 78, the title compound (843 mg) was obtained.

Sources & evidence

ORD record
ord-8a6d05e23fd048189017a532f8a2475b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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