Ethanol → HCID 86676778, compound

Participants

Reaction Steps

Ammonium chloride (504 mg) and iron (364 mg) were added to a solution of ethanol (9 mL) and water (2.3 mL), [4-(2,4-dimethylphenyl)piperazin-1-yl][4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-nitrophenyl]methanone (770 mg) described in Example 100 was added while stirring at 60° C.-70° C. After completion of the reaction, the insoluble material was collected by filtration, and the filtrate was concentrated. To the obtained residue was added aqueous sodium hydrogen carbonate solution, the mixture was extracted with ethyl acetate, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (380 mg).

Provenance & Evidence