Hydrochloric Acid → HCID 71261264, compound

Participants

Reaction Steps

[2-Amino-4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (100 mg) described in Example 103 was dissolved in pyridine (2 mL), 4-fluorophenyl isocyanate (64 mg) was added, and the mixture was stirred at room temperature. After completion of the reaction, to the reaction mixture was added dilute hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated. The obtained residue was purified by column chromatography (chloroform:methanol) to give the title compound (89 mg).

Provenance & Evidence