1-(2,6-Dimethylpyridin-3-yl)piperazine → [4-(2,6-Dimethylpyridin-3-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorophenyl]methanone

Participants

Reaction Steps

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-fluorobenzoic acid (291 mg) described in Preparation Example 23 and 1-(2,6-dimethylpyridin-3-yl)piperazine (215 mg) described in Preparation Example 94 and by the reaction and treatment in the same manner as in Example 87, the title compound (175 mg) was obtained.

Provenance & Evidence