1-(2,4-Xylyl)piperazine → HCID 71252671, compound

HRID 2411489Notes

Reaction equation

HRID 2411489 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=1[F:16].[CH3:18][C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:18][C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=1[N:26]1[CH2:27][CH2:28][N:29]([C:11]([C:10]2[CH:14]=[CH:15][C:7]([N:3]3[CH2:4][CH2:5][CH2:6][S:2]3(=[O:1])=[O:17])=[C:8]([F:16])[CH:9]=2)=[O:13])[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 63190272HCID 63190272, compound

Product 1

HCID 71252671HCID 71252671, compoundYield 57.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-3-fluorobenzoic acid (272 mg) described in Preparation Example 26 and 1-(2,4-dimethylphenyl)piperazine (199 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (258 mg) was obtained.

Sources & evidence

ORD record
ord-1d9d35f044df4da1a3832bb87cbe295c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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