3-Chloropropanesulphonyl chloride → HCID 71252318, compound

HRID 2411490Notes

Reaction equation

HRID 2411490 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[CH:3]=1.Cl[CH2:31][CH2:32][CH2:33][S:34](Cl)(=[O:36])=[O:35]>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:1]3[CH2:31][CH2:32][CH2:33][S:34]3(=[O:36])=[O:35])=[CH:3][C:4]=2[N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)=[O:9])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 86676760HCID 86676760, compound

Product 1

HCID 71252318HCID 71252318, compound

Procedure

Using [4-amino-2-(morpholin-4-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (188 mg) described in Preparation Example 151 and 3-chloropropane-1-sulfonyl chloride (0.08 mL) and by the reaction and treatment in the same manner as in Preparation Example 78, the title compound (82 mg) was obtained.

Sources & evidence

ORD record
ord-5cfd496d34794fb48047a099219ec26a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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