HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid | HCID 6625011 | — |
| Reactant | 1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine dihydrochloride | HCID 19836943 | — |
| Product | [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)phenyl][4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 55433511 | 85.6% |
Reaction Steps
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (253 mg) described in Preparation Example 16 and 1-(5-trifluoromethylpyridin-2-yl)piperazine dihydrochloride (319 mg) and by the reaction and treatment in the same manner as in Example 94, the title compound (408 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-136b92b5798b40bca7855af6ce25739a |
| Source note | uspto-grants-2014_08 |