1-(2,4-Xylyl)piperazine → [4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(imidazo[4,5-b]pyridin-3-yl)phenyl]methanone

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Xylyl)piperazine	HCID 70544	—
Reactant	Ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate	HCID 71252216	—
Product	[4-(2,4-Dimethylphenyl)piperazin-1-yl][4-(imidazo[4,5-b]pyridin-3-yl)phenyl]methanone	HCID 71253257	73.2%

Reaction Steps

Using ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate (300 mg) described in Preparation Example 77 and 1-(2,4-dimethylphenyl)piperazine (214 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (338 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816079B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-702b53c55fd64f768e3a2322875ff712
Source note	uspto-grants-2014_08