4-(4-Chlorobenzoyl)Piperidine → [4-(4-Chlorobenzoyl)piperidin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

HRID 2411495Notes

Reaction equation

HRID 2411495 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[Cl:19][C:20]1[CH:33]=[CH:32][C:23]([C:24]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:25])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:24]([CH:26]2[CH2:31][CH2:30][N:29]([C:11]([C:10]3[CH:9]=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:28][CH2:27]2)=[O:25])=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 27771154-(4-Chlorobenzoyl)PiperidineHCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

Product 1

HCID 71252872[4-(4-Chlorobenzoyl)piperidin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanoneYield 6.2%

Procedure

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (363 mg) described in Preparation Example 25 and 4-(4-chlorobenzoyl)piperidine (300 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (37 mg) was obtained.

Sources & evidence

ORD record
ord-825008482e8b464cb8150758582f6b62
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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