1-(2,4-Xylyl)piperazine → HCID 71252121, compound

HRID 2411499Notes

Reaction equation

HRID 2411499 reaction equation
[N:1]1([C:6]2[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[N:23]1[CH2:24][CH2:25][N:26]([C:10]([C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)=[CH:14][CH:13]=2)=[O:12])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27955154-(Pyrrolidin-1-yl)benzoic acid

Product 1

HCID 71252121HCID 71252121, compoundYield 4.2%

Procedure

Using 4-(pyrrolidin-1-yl)benzoic acid (200 mg) and 1-(2,4-dimethylphenyl)piperazine (199 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (15.8 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-06aee11632194b10baf74e8845fb4575
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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