3-Chloropropanesulphonyl chloride → HCID 71251966, compound

HRID 2411501Notes

Reaction equation

HRID 2411501 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:22]=3[CH3:28])[CH2:17][CH2:16]2)=[O:14])=[C:6]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:7]=1.Cl[CH2:30][CH2:31][CH2:32][S:33](Cl)(=[O:35])=[O:34]>>[CH3:28][C:22]1[CH:23]=[C:24]([CH3:27])[CH:25]=[CH:26][C:21]=1[N:18]1[CH2:17][CH2:16][N:15]([C:13]([C:5]2[CH:4]=[CH:3][C:2]([N:1]3[CH2:30][CH2:31][CH2:32][S:33]3(=[O:35])=[O:34])=[CH:7][C:6]=2[NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[O:14])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 86676762HCID 86676762, compound

Product 1

HCID 71251966HCID 71251966, compound

Procedure

Using N-{5-amino-2-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}methanesulfonamide (588 mg) described in Preparation Example 153 and 3-chloropropane-1-sulfonyl chloride (0.23 mL) and by the reaction and treatment in the same manner as in Example 78, the title compound (94 mg) was obtained.

Sources & evidence

ORD record
ord-8a12b99806a5478b93df177de745cb74
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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