HCID 66820594, compound → HCID 59586210, compound

HRID 241151Notes

Reaction equation

HRID 241151 reaction equation
Cl.[CH:2]1([C:5]2[N:6](C(OC(C)CC)=O)[C:7]3[C:8]([N:24]=2)=[N:9][CH:10]=[C:11]([C:13]2[CH:14]=[CH:15][C:16]4[O:22][CH2:21][CH2:20][NH:19][CH2:18][C:17]=4[CH:23]=2)[CH:12]=3)[CH2:4][CH2:3]1.Cl[C:33]1[C:42]2[CH2:41][C:40]([CH3:44])([CH3:43])[CH2:39][CH2:38][C:37]=2[N:36]=[C:35]([CH3:45])[N:34]=1>>[CH:2]1([C:5]2[NH:6][C:7]3[C:8]([N:24]=2)=[N:9][CH:10]=[C:11]([C:13]2[CH:14]=[CH:15][C:16]4[O:22][CH2:21][CH2:20][N:19]([C:33]5[C:42]6[CH2:41][C:40]([CH3:43])([CH3:44])[CH2:39][CH2:38][C:37]=6[N:36]=[C:35]([CH3:45])[N:34]=5)[CH2:18][C:17]=4[CH:23]=2)[CH:12]=3)[CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 66820594HCID 66820594, compoundHCID 86647843HCID 86647843, compound

Product 1

HCID 59586210HCID 59586210, compound

Procedure

Prepared according to the method of example 6 by using 1-methylpropyl 2-cyclopropyl-6-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-1H-imidazo[4,5-b]pyridine-1-carboxylate hydrochloride (reagent preparation 19) and 4-chloro-2,6,6-trimethyl-5,6,7,8-tetrahydroquinazoline (reagent preparation 8) in step 3. 1H NMR (400 MHz, methanol-d4) δ 8.50 (s, 1H), 7.98 (s, 1H), 7.61 (d, 1H), 7.49 (dd, 1H), 7.09 (d, 1H), 4.71 (s, 2H), 4.32 (m, 2H), 3.97 (m, 2H), 2.75 (t, 2H), 2.46 (s, 2H), 2.40 (s, 3H), 2.21 (m, 1H), 1.66 (t, 2H), 1.22 (m, 4H), 0.91 (s, 6H); MS (EI) for C29H32N6O: 481 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ae15afaec07d47b3b8f9aae81f487678
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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