Acetyl chloride → HCID 71253323, compound

HRID 2411510Notes

Reaction equation

HRID 2411510 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][S:9]2(=[O:14])=[O:13])[CH:5]=[CH:4][C:3]=1[C:15]([N:17]1[CH2:22][CH2:21][N:20]([C:23]2[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[CH:25][N:24]=2)[CH2:19][CH2:18]1)=[O:16].[C:31](Cl)(=[O:33])[CH3:32]>>[CH3:29][C:28]1[C:23]([N:20]2[CH2:19][CH2:18][N:17]([C:15]([C:3]3[CH:4]=[CH:5][C:6]([N:8]4[CH2:12][CH2:11][CH2:10][S:9]4(=[O:13])=[O:14])=[CH:7][C:2]=3[NH:1][C:31](=[O:33])[CH3:32])=[O:16])[CH2:22][CH2:21]2)=[N:24][CH:25]=[C:26]([CH3:30])[CH:27]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 86676780HCID 86676780, compound

Product 1

HCID 71253323HCID 71253323, compound

Procedure

Using [2-amino-4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (300 mg) described in Example 136 and acetyl chloride (0.07 mL) and by the reaction and treatment in the same manner as in Example 107, the title compound (279 mg) was obtained.

Sources & evidence

ORD record
ord-1ca686eb9b454681bb1962005b184326
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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