Methyl 1,1-dioxo-1lambda6,2-thiazolidine-3-carboxylate → 2-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-1,1-dioxo-1lambda6-isothiazolidine-3-carboxylic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methyl 1,1-dioxo-1lambda6,2-thiazolidine-3-carboxylate	HCID 11240805	—
Reactant	[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone	HCID 58484733	—
Product	2-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-1,1-dioxo-1lambda6-isothiazolidine-3-carboxylic acid methyl ester	HCID 71252794	4.7%

Reaction Steps

Using [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (781 mg) described in Preparation Example 108 and 1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid methyl ester (580 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (41 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816079B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-5e7d66a93fb0447c935c029fab3620f4
Source note	uspto-grants-2014_08