4-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acid → HCID 71252229, compound

HRID 2411512Notes

Reaction equation

HRID 2411512 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][C:19]=1[N:25]1[CH2:26][CH2:27][N:28]([C:11]([C:10]2[CH:9]=[CH:8][C:7]([N:3]3[CH2:4][CH2:5][CH2:6][S:2]3(=[O:1])=[O:16])=[CH:15][CH:14]=2)=[O:13])[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 66250114-(1,1-Dioxo-1,2-thiazolidin-2-yl)benzoic acidHCID 83698021HCID 83698021, compound

Product 1

HCID 71252229HCID 71252229, compoundYield 37%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (165 mg) described in Preparation Example 16 and 1-(4,6-dimethylpyridin-3-yl)piperazine (131 mg) described in Preparation Example 95 and by the reaction and treatment in the same manner as in Example 87, the title compound (105 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 95 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-faf23f81743c48038868149fadfc4e55
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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