HCID 11229370, compound → HCID 71252102, compound

HRID 2411513Notes

Reaction equation

HRID 2411513 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:24]1([C@@H:30]2[CH2:34][CH2:33][S:32](=[O:36])(=[O:35])[NH:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:31]4[C@H:30]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[CH2:34][CH2:33][S:32]4(=[O:35])=[O:36])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 11229370HCID 11229370, compoundHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252102HCID 71252102, compoundYield 56.1%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (421 mg) described in Preparation Example 113 and (S)-3-phenylisothiazolidine 1,1-dioxide (197 mg) described in Preparation Example 27 and by the reaction and treatment in the same manner as in Example 1, the title compound (275 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 27 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-baf95323338d4a5db22f6a1ea76b78cb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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