(R)-3-methylisothiazolidine 1,1-dioxide → (R)-[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl][2-methyl-4-(3-methyl-1,1-dioxo-1lambda6-isothiazolidin-2-yl)phenyl]methanone

Participants

Reaction Steps

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methylphenyl)methanone (562 mg) described in Preparation Example 154 and (R)-3-methylisothiazolidine 1,1-dioxide (175 mg) described in Preparation Example 2 and by the reaction and treatment in the same manner as in Example 1, the title compound (296 mg) was obtained.

Provenance & Evidence