(R)-3-methylisothiazolidine 1,1-dioxide → HCID 71252163, compound

HRID 2411519Notes

Reaction equation

HRID 2411519 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][C:18]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:28][C@@H:29]1[CH2:33][CH2:32][S:31](=[O:35])(=[O:34])[NH:30]1>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:30]4[C@H:29]([CH3:28])[CH2:33][CH2:32][S:31]4(=[O:35])=[O:34])=[CH:19][C:18]=3[S:24]([CH3:27])(=[O:26])=[O:25])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 16664802(R)-3-methylisothiazolidine 1,1-dioxideHCID 71251932HCID 71251932, compound

Product 1

HCID 71252163HCID 71252163, compoundYield 57.3%

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodo-2-methanesulfonylphenyl)methanone (580 mg) described in Preparation Example 156 and (R)-3-methylisothiazolidine 1,1-dioxide (157 mg) described in Preparation Example 2 and by the reaction and treatment in the same manner as in Example 1, the title compound (337 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 2 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-baecc9d8a16549a7aec9ac8e18719c63
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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