1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 54675479, compound

HRID 2411521Notes

Reaction equation

HRID 2411521 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][C:8]=1[F:16].[CH3:18][C:19]1[C:20]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1>>[CH3:18][C:19]1[C:20]([N:26]2[CH2:27][CH2:28][N:29]([C:11]([C:10]3[CH:14]=[CH:15][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:17])=[C:8]([F:16])[CH:9]=3)=[O:13])[CH2:30][CH2:31]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 63190272HCID 63190272, compound

Product 1

HCID 54675479HCID 54675479, compoundYield 61.8%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-3-fluorobenzoic acid (223 mg) described in Preparation Example 26 and 1-(3,5-dimethylpyridin-2-yl)piperazine (164 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (229 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-8c4ae066dc9c4ddea4ecae202c9fbeec
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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