HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorophenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride | HCID 67381091 | — |
| Reactant | 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorobenzoic acid | HCID 71252861 | — |
| Product | [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorophenyl]methanone | HCID 71252725 | 62.9% |
Reaction Steps
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-fluorobenzoic acid (259 mg) described in Preparation Example 23 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (254 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Example 86, the title compound (288 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-f1d645fc7df7462ba62c278b9f9c2dfa |
| Source note | uspto-grants-2014_08 |