1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-fluorophenyl][4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone

Participants

Reaction Steps

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-fluorobenzoic acid (259 mg) described in Preparation Example 23 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (245 mg) described in Preparation Example 84 and by the reaction and treatment in the same manner as in Example 87, the title compound (332 mg) was obtained.

Provenance & Evidence