HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methyl-2-trifluoromethylphenyl)piperazine → [6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl][4-(4-methyl-2-trifluoromethylphenyl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methyl-2-trifluoromethylphenyl)piperazine | HCID 21363835 | — |
| Reactant | Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate | HCID 71251937 | — |
| Product | [6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl][4-(4-methyl-2-trifluoromethylphenyl)piperazin-1-yl]methanone | HCID 71252424 | 27.4% |
Reaction Steps
Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (363 mg) described in Preparation Example 25 and 1-(4-methyl-2-trifluoromethylphenyl)piperazine (327 mg) described in Preparation Example 96 and by the reaction and treatment in the same manner as in Example 109, the title compound (172 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7ab6cfc332d34c1197d775d19b0d5df1 |
| Source note | uspto-grants-2014_08 |