52962-52-4 → HCID 71253108, compound

HRID 2411552Notes

Reaction equation

HRID 2411552 reaction equation
[O:1]=[S:2]1(=[O:16])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1.[CH:17]1([C:20]2[C:21]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)=[N:22][CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[C:21]([N:30]3[CH2:35][CH2:34][N:33]([C:11]([C:10]4[CH:9]=[CH:8][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:16])=[CH:15][CH:14]=4)=[O:13])[CH2:32][CH2:31]3)=[N:22][CH:23]=[C:24]([C:26]([F:29])([F:27])[F:28])[CH:25]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 662501152962-52-4HCID 584847721-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine

Product 1

HCID 71253108HCID 71253108, compoundYield 81.2%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (241 mg) described in Preparation Example 16 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (271 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87, the title compound (401 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-740cf95ec00d403b9ad8fc2e36fea111
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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