HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride | HCID 67381091 | — |
| Reactant | 4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid | HCID 71252082 | — |
| Product | [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][4-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl]methanone | HCID 71252021 | 73% |
Reaction Steps
Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxybenzoic acid (271 mg) described in Preparation Example 19 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (254 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Example 86, the title compound (343 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-6c385f35f42840c98fd2c68210fefba6 |
| Source note | uspto-grants-2014_08 |