1-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine → HCID 71252926、化合物

HRID 2411557ノート

反応式

HRID 2411557 の反応式
[CH3:1][S:2]([C:5]1[CH:15]=[C:14]([N:16]2[C@H:20]([CH3:21])[CH2:19][CH2:18][S:17]2(=[O:23])=[O:22])[CH:13]=[CH:12][C:6]=1[C:7](OCC)=[O:8])(=[O:4])=[O:3].[CH:24]1([C:27]2[C:28]([N:37]3[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]3)=[N:29][CH:30]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:32]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[C:28]([N:37]3[CH2:42][CH2:41][N:40]([C:7]([C:6]4[CH:12]=[CH:13][C:14]([N:16]5[C@H:20]([CH3:21])[CH2:19][CH2:18][S:17]5(=[O:22])=[O:23])=[CH:15][C:5]=4[S:2]([CH3:1])(=[O:3])=[O:4])=[O:8])[CH2:39][CH2:38]3)=[N:29][CH:30]=[C:31]([C:33]([F:36])([F:34])[F:35])[CH:32]=2)[CH2:25][CH2:26]1

参加物

3

反応物 2

HCID 584847721-(3-Cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazineHCID 71261164HCID 71261164、化合物

生成物 1

HCID 71252926HCID 71252926、化合物収率 58.5%

実験手順

Using ethyl (R)-2-methanesulfonyl-4-(3-methyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoate (181 mg) described in Preparation Example 28 and 1-(3-cyclopropyl-5-trifluoromethylpyridin-2-yl)piperazine (136 mg) described in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 109, the title compound (172 mg) was obtained.

後処理

  1. customdescribed in Preparation Example 90 and by the reaction and treatment in the same manner as in Example 109

出典と根拠

ORDレコード
ord-06a2988241c04068ba0523dfc1a9ab87
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…