HRID2411559

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67381091

未命名化合物

结构：O=C(O)c1ccc(N2CCCS2(=O)=O)cc1N1CCCS1(=O)=O

HCID71252293

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(N3CCCS3(=O)=O)cc2N2CCCS2(=O)=O)CC1

HCID71252530

未命名化合物

收率 37%

PROCEDURE

实验过程

Using 2,4-bis(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoic acid (200 mg) described in Preparation Example 34 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (141 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Example 86, the title compound (115 mg) was obtained.

WORKUP

后处理

customdescribed in Preparation Example 82 and by the reaction and treatment in the same manner as in Example 86

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-82f7ab3246414fe78a29e0e726e1c7a9
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:8]=1[C:9](O)=[O:10].Cl.[CH:25]1([C:28]2[CH:29]=[C:30]([CH3:40])[C:31]([N:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)=[N:32][CH:33]=2)[CH2:27][CH2:26]1>>[O:23]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:21])=[O:22])[CH:13]=[CH:12][C:8]=1[C:9]([N:37]1[CH2:36][CH2:35][N:34]([C:31]2[C:30]([CH3:40])=[CH:29][C:28]([CH:25]3[CH2:27][CH2:26]3)=[CH:33][N:32]=2)[CH2:39][CH2:38]1)=[O:10]