1-(3,5,6-Trimethylpyridin-2-yl)piperazine → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl][4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411570Notes

Reaction equation

HRID 2411570 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([O:16][CH3:17])[CH:8]=1.[CH3:19][C:20]1[C:21]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:22][C:23]([CH3:27])=[C:24]([CH3:26])[CH:25]=1>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:31]2[CH2:32][CH2:33][N:28]([C:21]3[C:20]([CH3:19])=[CH:25][C:24]([CH3:26])=[C:23]([CH3:27])[N:22]=3)[CH2:29][CH2:30]2)=[O:13])=[C:9]([O:16][CH3:17])[CH:8]=1

Participants

3

Reactant 2

HCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 712520824-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxybenzoic acid

Product 1

HCID 71252431[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methoxyphenyl][4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 60%

Procedure

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methoxybenzoic acid (136 mg) described in Preparation Example 19 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (103 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 87, the title compound (138 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-3f611d7487604d1a9e128d63fd6e77cc
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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