1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

Participants

Role	Name	HCID	Charge
Reactant	1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride	HCID 67381091	—
Reactant	Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate	HCID 71251937	—
Product	[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone	HCID 71252609	3.9%

Reaction Steps

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (270 mg) described in Preparation Example 25 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (254 mg) described in Preparation Example 82 and by the reaction and treatment in the same manner as in Example 170, the title compound (17 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08816079B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-f3993858f51d45c5bc549a630642b0ea
Source note	uspto-grants-2014_08