1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252808, compound

HRID 2411573Notes

Reaction equation

HRID 2411573 reaction equation
[CH3:1][C:2]1([CH3:20])[CH2:6][S:5](=[O:8])(=[O:7])[N:4]([C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=O)=[CH:11][CH:10]=2)[CH2:3]1.[CH3:21][C:22]1[C:23]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[N:24][CH:25]=[C:26]([CH3:28])[CH:27]=1>>[CH3:20][C:2]1([CH3:1])[CH2:6][S:5](=[O:7])(=[O:8])[N:4]([C:9]2[CH:10]=[CH:11][C:12]([C:13]([N:32]3[CH2:33][CH2:34][N:29]([C:23]4[C:22]([CH3:21])=[CH:27][C:26]([CH3:28])=[CH:25][N:24]=4)[CH2:30][CH2:31]3)=[O:15])=[CH:18][CH:19]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71251961HCID 71251961, compound

Product 1

HCID 71252808HCID 71252808, compoundYield 21.2%

Procedure

Using ethyl 4-(4,4-dimethyl-1,1-dioxo-1λ6-isothiazolidin-2-yl)benzoate (127 mg) described in Preparation Example 30 and 1-(3,5-dimethylpyridin-2-yl)piperazine (82 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (40 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-9686ef84be574c79a41ed8aa0200efa0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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