1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71261293, compound

HRID 2411574Notes

Reaction equation

HRID 2411574 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1([C:10]2[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[CH:12][CH:11]=2)[CH2:9][CH2:8]1.[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:30][CH2:31][N:32]([C:14]([C:13]4[CH:17]=[CH:18][C:10]([C:7]5([N:3]6[CH2:4][CH2:5][CH2:6][S:2]6(=[O:19])=[O:1])[CH2:9][CH2:8]5)=[CH:11][CH:12]=4)=[O:15])[CH2:33][CH2:34]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252841HCID 71252841, compound

Product 1

HCID 71261293HCID 71261293, compoundYield 32.8%

Procedure

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)cyclopropyl]benzoic acid (141 mg) described in Preparation Example 31 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (114 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (79 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-df644dae068d496babebf179c958a747
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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