1-(2,4-Xylyl)piperazine → HCID 71252645, compound

HRID 2411575Notes

Reaction equation

HRID 2411575 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1.[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:29][CH2:30][N:31]([C:14]([C:13]2[CH:17]=[CH:18][C:10]([C:7]3([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:19])[CH2:8][CH2:9]3)=[CH:11][CH:12]=2)=[O:16])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 71252841HCID 71252841, compound

Product 1

HCID 71252645HCID 71252645, compoundYield 80.7%

Procedure

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)cyclopropyl]benzoic acid (141 mg) described in Preparation Example 31 and 1-(2,4-dimethylphenyl)piperazine (95.1 mg) and by the reaction and treatment in the same manner as in Example 87, the title compound (183 mg) was obtained.

Sources & evidence

ORD record
ord-d4a04b4554a847038f9514b7edbb95bc
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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